The Best Enzyme Cleaner for Dog Urine Rated

It takes more than a quick wipe to clean up an accident when your dog “goes” in the house. Those stinky odors can linger for days, and if your dog keeps having accidents, the problem just gets worse. Instead of covering up the problem, get to the root of the odor with an enzyme cleaner for dog urine! 

What is an Enzyme Cleaner?

Enzyme cleaners are specifically formulated with enzymes that target the proteins and bacteria in dog urine that create stains and odors. Any dog owner will tell you that using a regular disinfectant spray works once or twice, but after a few pees, you need those enzymes to break down the lingering smell. 

Most enzyme cleaners can safely be used on all surfaces, including soft surfaces like carpets and mattresses, and sometimes finicky surfaces like hardwood. Use it as a spot treatment, add to a load of laundry, or use it to wash anything in your home. 

Best Dog Urine Enzyme Cleaners

How you choose the best enzyme cleaner for dog urine really depends on what you are looking for. If you are looking for the best option on the market no matter what it is, choose the one with the most reviews, or one with the best rating and lots of reviews. If you want to make sure you use only natural ingredients in your home, there’s an option for that, too. 

AwardProductPriceRatingDetails
Most Highly Rated


 Nature’s Miracle Enzymatic Formula Stain & Odor Remover
Total: $29.49
Per oz: $0.23
Buy On Amazon
5/5 – 5,700 ratingsNatural enzymatic formulaChlorine-freeSafe for all surfaces including carpetCan be used with laundry
Most Popular

Rocco & Roxie Stain & Odor Eliminator for Strong Odor (32 oz.)
Total: $14.98 
Per oz: $0.46
Buy On Amazon
4.5/5 – 95,000 ratingsNatural bio-enzymatic formulaChlorine-freeSafe for all surfaces including carpetCan be used with laundry
Most Expensive

Wee Care Toilet Cleaner for Dogs (16 oz.)
Total: $9.49
Per oz: $0.59
Buy On Amazon
4/5 – 1,300 ratingsNatural enzymatic formulaBiodegradableNon-toxic and chemical freeEco-friendly
Best All-Natural

TriNova Natural Pet Stain & Odor Remover
Total: $17.97
Per oz: $0.56
Buy On Amazon
4.5/5 – 3,000 ratingsNatural bio-enzymatic formula100% organicPlant-basedSafe on all surfaces including carpets
Editor’s Choice
Simple Solution Extreme Stain & Odor RemoverTotal: $13.79
Per oz: $0.43
Buy On Amazon
4.5/5 – 27,000 ratingsProfessional strengthUse for dog and cat urineSafe for all surfaces3-in-1 nozzle 

1. Most Highly Rated: Nature’s Miracle

Enzyme Cleaner for Dog Urine - Nature’s Miracle

Buy On Amazon for $29.49

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Nature’s Miracle is a well-known natural pet cleaning product brand with amazing reviews on Amazon for all of their products! This particular product is one of their most popular and scored an impressive five out of five stars from its 5,700 reviewers. Use this enzyme cleaner for dog urine, feces, vomit, and other mysterious stains whether you need to do a spot treatment, clean an entire rug, or wash your floors. 

Enzyme Cleaner for Dog Urine - Rocco & Roxie Stain & Odor Eliminator

Buy On Amazon for $14.98

With a whopping 95,000 reviews and counting, this is easily the best enzyme cleaner for dog urine if you’re looking for the best-selling options! Chlorine-free and safe to use on rugs and laundry without risking color-bleeding, this bio-enzymatic cleaner from Rocco & Roxie can be used on literally any surface from hardwood floors to your most delicate clothing items. 

3. Most Expensive: Wee Care

Wee Care-Enzyme Cleaner for Dog Urine

Buy On Amazon for $9.49

Free from harsh chemicals and toxic ingredients, this enzyme cleaner from Wee Care is our most expensive option on the list. While it’s not jaw-droppingly expensive, it’s quite a bit more expensive per ounce than other cleaners on this list, and its reviewers aren’t all thrilled with their purchase. The biggest complaints have been the occasional packaging issue and a few customers who wish it smelled a little stronger. So, if you’re looking for a very lightly scented urine cleaner, this might be a good option. 

4. All Natural: TriNova

TriNova -Enzyme Cleaner for Dog Urine

Buy On Amazon for $17.97

Made from 100% natural, plant-based, and organic ingredients, Pet Stain & Odor Remover from TriNova is undoubtedly the best enzyme cleaner for dog urine if you’re looking for a non-toxic option. Safer for the planet, your family, and your home, reviewers also say this product is super-effective. 

5. Editors Choice: Simple Solution

Enzyme Cleaner for Dog Urine - Simple Solution

Buy On Amazon for $13.79

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If you’re dealing with caked-on, or hard-to-remove stains, you need an extreme solution. Professional-strength stain and odor removal is easy with Simple Solution’s advanced formula designed to get rid of even the biggest messes. Use on dog urine or cat urine for excellent results. 

Enzymatic Cleaner FAQ

If you still have more questions about using enzymatic dog urine remover, you’re not alone! Here are some of the most common questions asked by dog owners like you. 

What Enzyme Neutralizes Dog Urine?

Dog on a fresh, clean carpet

Proteolytic enzymes, which break down proteins, are used in enzymatic dog urine cleaners. The proteins in dog urine are primarily responsible for the coloration and the odor, so the addition of these protein-dissolving enzymes helps to eliminate the smell and stain 

Do Enzyme Cleaners Work On Dog Urine?

Yes, they sure do! Check out the options we’ve listed above. 

Is Vinegar An Enzymatic Cleaner For Dog Urine?

No, vinegar is not an enzymatic cleaner for dog urine, since it does not contain proteolytic enzymes. Vinegar does work to reduce urine smell by killing the bacteria, but it won’t work on the proteins. 

What Is The Best Product To Clean Up Dog Pee?

Enzymatic dog urine cleaners of any kind will work well on dog pee! The one you choose is up to you. 

Enzyme Cleaner For Dog Urine

Can You Make Homemade Enzyme Cleaner For Dog Urine?

Yes! Some dishwashing liquids contain protein-destroying enzymes to help break down food residue. Make a simple homemade enzyme cleaner by combining a few drops of dishwashing liquid with one part hydrogen peroxide to three parts water, and spray away!

What’s The Best Enzyme Cleaner For Dog Urine On Hardwood Floors?

All of the enzyme cleaners we’ve featured in this article are safe for use on hardwood floors. 

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What’s the Best Enzyme Carpet Cleaner For Dog Urine?

All of the enzyme cleaners we’ve featured in this article are safe for use on carpets!

Enzyme Cleaner For Dog Urine

What’s the Best Enzyme Cleaner For Dog Urine Outdoors?

You can use any of the enzyme cleaners in this article outdoors, but in general, you shouldn’t have to. The rain and earth will break down the urine for you. 

What’s the Best Enzyme Cleaner For Dog Urine and Poop?

All of the enzyme cleaners we’ve featured in this article work well on both urine and poop. 

Once your home is clean, give your pooch a wash using one of these best-selling dog shampoos!

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